The Humberto Vidal Explosion was a gas explosion that occurred on November 21, 1996 on the Humberto Vidal shoe store located in Río Piedras, Puerto Rico, United States. The explosion killed 33 and wounded 69 others when the building collapsed.

Most of the victims were inside the building at the moment of the explosion, but others were in the streets surrounding the building. After the explosion, bodies of victims were placed in the pavement in front of the nearby La Milagrosa Church, where Luis Cardinal Aponte Martínez administered last rites.

United States President Bill Clinton quickly declared Puerto Rico a disaster area, which ensured the receipt of federal aid to help the victims, including the NTSB which launched an investigation. San Juan Gas Company, owned by Enron Corporation, quickly denied any responsibility claiming that the building had no gas service at the moment. An investigation of the explosion was quickly initiated.