The MGM Grand Fire was a 1980 fire at the MGM Grand Hotel and Casino in Las Vegas, Nevada, USA, that killed 85 people, most through smoke inhalation. The tragedy remains the worst disaster in Nevada history, and the second-worst hotel fire in modern U.S. history, after the 1946 Winecoff Hotel fire that killed 119.

At the time of the fire, approximately 5,000 people were in the hotel and casino, a 26-story luxury resort with more than 2,000 hotel rooms. Just after 7:00 on the morning of November 21, 1980, a fire broke out in the Deli, a restaurant. Smoke and fire spread through the building, killing 85 people and injuring 650, including guests, employees and 14 firefighters.

While the fire primarily damaged the second floor casino and adjacent restaurants, most of the deaths were caused by smoke inhalation on the upper floors of the hotel. Openings in vertical shafts (elevators and stairwells) and seismic joints allowed toxic smoke to spread to the top floor.